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However, it is important to note that GSH is in equilibrium with GSSG and that this delicate balance is maintained via a complex multi-protein system containing the GSH synthesis proteins

Collectively, our findings demonstrate that the GPX4 inhibition by RSL3 in PTC cells induces cell death, ferroptosis, lipid peroxidation, increased intracellular ROS burden, and significantly impairs thyroid tumor cell migration, 3D PTC spheroid fotmation and results in reduced spheroid viability in vitro

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