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1 There are few published cases of PSM of extramedullary origin

It is metabolically active tissue linked to increased risk of cardiovascular disease, type 2 diabetes, and chronic inflammation

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The confusion stems from conflating pharmacokinetics (how long the compound circulates) with pharmacodynamics (how long the biological response persists)

10.1016/S0893-133X(02)00306-8 97

The transcriptional activation of genes encoding other enzymes of the PPP also occurs in response to oxidative stress and the demands of increased anabolic metabolism