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10.1096/fj.202200397R 8 ChenZ.WangY.ZhangG.ZhengJ.TianL.SongY.et al (2024b)

This is why many report excessive shedding on semaglutide several weeks after major progress on the scale

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Single-nucleus RNA-sequencing shows opposing effects of GIPR agonism and antagonism in the hindbrain, with antagonism, but not agonism, mimicking GLP-1R signalling and with GIPR antagonism and GLP-1R agonism both regulating gene programmes implicated in synaptic plasticity

So which program comes out on top

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