42 Conjugation by esters and disulfide bonds allows enzymes to cleave the lipids from the drug once it has passively entered the CNS, thus making the drug polar and trapping it inside
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It happens in men, too
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434 However, in another study targeting germline BRCA1/2 wild-type TNBC, it is found that neoadjuvant olaparib does not improve pCR rates, event-free survivial (EFS), or OS when added to carboplatin-paclitaxel and anthracycline-based chemotherapy
doi: 10.3390/pharmaceutics15092337 26