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Causes and Symptoms The exact factors that cause shingles is unknown

Cell Adh Migr 3(1):107117 Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ (2020) MAFG-driven astrocytes promote CNS inflammation

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Cyt-C binds to Apaf-1 to form an apoptosome, triggering the Caspase cascade, leading to cell destruction and apoptosis (201, 204)