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J Clin Invest 90 : 23482354 Biolo G et al

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In developed countries, situations at greatest risk for deficiency include eating a diet restricted in fruits and vegetables, smoking or long-term exposure to secondhand smoke, and drug and alcohol abuse

For most patients over 40 with mixed goals (fat loss, anti-aging, and recovery), CJC-1295/Ipamorelin is the most commonly recommended starting protocol because of its broad effects across the systems most affected by age-related GH decline