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Takayanagi, 2007)

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-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas

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7.4.4 Next-generation agonists The development of dual GLP-1/GIP receptor agonists (e.g., tirzepatide) and novel blood-brain barrier-penetrant formulations may offer superior neuroprotective efficacy by more potently engaging central receptors or providing a broader spectrum of action ( 7.5 Limitations of current evidence Several limitations must be considered when interpreting the current evidence

For patients with significant obesity and metabolic risk who are not currently on pharmacotherapy, initiating a supervised GLP-1 or dual agonist program now, rather than deferring to an uncertain future approval date, is clinically sensible