The gut microbiome, shaped by genetic, environmental, and lifestyle factors, plays a crucial role in immune, metabolic, and neural development, with dysbiosis increasingly implicated in the pathogenesis of neurological disorders such as stroke, PD, and AD (Sorboni et al., 2022)
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A deficiency in Ptgs2 (encoding cyclooxygenase 2) in fibroblasts increases T cell activation and enhances the antimetastatic activity of immunotherapies [73]
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As pregnancy advances and the placenta develops, the expression of OCT2 in the placenta increases, which facilitates the transport of metformin through these channels
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