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Patients should understand that whilst GLP-1 medications do act on the brain, their neurological effects are primarily related to appetite regulation and glucose sensing rather than direct neurotransmitter manipulation

"Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2)." Lancet

Joshi G, Gonenc A, DiSalvo M, Faraone SV, Ceranoglu TA, Yule AM, et al

The conclusion was further validated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and H&E staining (Fig

So something like a time-restricted diet is feasible. But the key to success with diet-related issues is consistency

It also means the drowsiness effect will hit you during your waking hours, which most patients find disruptive