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Biochemistry 27 , 85098515 (1988)
Because cobalamin in normally absorbed from food through the gastrointestinal tract, chronic diseases that adversely affect the ability of the intestines to absorb nutrients (inflammatory bowel disease is an excellent example) can lead to cobalamin deficiency
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Protocol 3: the twice-weekly split dose approach Goal: Flatten the concentration curve to eliminate end-of-week symptom return Schedule (any compounded GLP-1): Take half your weekly dose every 3.5 days (e.g., Monday morning and Thursday evening) Total weekly dose remains identical Escalate total weekly dose at the same rate as your original plan Why the plotter supports this: The plotter shows a dramatic difference between once-weekly and twice-weekly dosing curves at the same total weekly dose
Curran J, Burkhoff D, Kloner RA
