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4.1.3 Mice and in vivo experiments All animal experiments were approved by The Institute of Cancer Research Animal Welfare and Ethical Review Body and performed in accordance with the UK Home Office Animals (Scientific Procedures) Act 1986, the UK National Cancer Research Institute guidelines for the welfare of animals in cancer research and the ARRIVE (animal research: reporting in-vivo experiments) guidelines

Therefore, different GSH-degrading enzymes exhibit different effects on cancer, either promoting or suppressing it, and their specific functions varies according to the type of tissue and tumor

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

Gut dysbiosis and increased intestinal permeability play a central role, triggered by activation of innate immune responses [16-19]

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The escalation schedules diverge