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Once a patient has SLD identified by imaging or biopsy, the next consideration is to screen the patient for cardio metabolic disease, where patients need one of the five cardio metabolic criteria to be fulfill the diagnosis of MASLD [Table 3]

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doi: 10.1016/j.molmet.2024.102006 52 NasteskaDHaradaNSuzukiKYamaneSHamasakiAJooEet al

As the bioactive form of vitamin B12, methyl-B12 plays a critical role in methylation pathwaysimpacting mood regulation, detoxification, and DNA repair

These findings underpin the interest in meldonium as a cardioprotective adjunct