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The Biden administration moved to a more expansive 1115 health-related social needs framework and approved 18 waivers authorizing evidence-based housing and nutrition services for specific high-need populations under this framework

However, peripheral distribution decreases the efficacy of oral therapy, requiring high doses, which causes potential systemic side effects (e.g., neutropenia)

Wismann, P

Understanding these potential pathways helps contextualize the limited available evidence and identify areas requiring further investigation

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This work was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (CC2106 (P.B.R.)), the UK Medical Research Council (CC2106 (P.B.R.)), and the Wellcome Trust (CC2106 (P.B.R.))