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Lentigines assume a particular importance when their presence is associated with a variety of inherited systemic conditions, including PeutzJeghers, LEOPARD (multiple lentigines) and Carneys syndromes, centrofacial lentiginosis, and LaugierHunziker syndrome (idiopathic lenticular mucocutaneous pigmentation)

The Sikiric groups foundational research, published in major pharmacology journals and indexed at the NIH National Library of Medicine, demonstrates direct gastroprotective and anti-inflammatory action in the gut mucosa

This article provides a comprehensive literature review of the natural history and management of Spitz nevi