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Documentation: Certificate of Analysis available where applicable

Preclinical Toxicology: Toxicity studies in rodents indicate that even high doses (e.g., 20 mg/kg) do not result in gross organ toxicity or lethality in the acute setting

Alkaloids contribute by activating Nrf2/HO-1 signaling, modulating the PINK1/Parkin pathway, and suppressing TLR4/NF-B and NLRP3 inflammasomes, while also upregulating Klotho protein levels [51]

10.1039/B915780H Metallomics

Medium was exchanged three times per week and organoids passaged with a split ratio of 1:6 every 714 days (Supplementary Fig

In vitro , PPOs can be activated by, among others, the treatment with proteases, which was attempted for jr PPO1-wt using three commercial serine proteases, namely nagarse, trypsin and proteinase K