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The off-cycle period allows the body natural repair mechanisms to operate independently and prevents dependence on exogenous peptide signaling

doi: 10.1523/jneurosci.1368-13.2013 180

This approach reduces toxicity, improves drug distribution throughout the body, and prolonged therapeutic benefits

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Exendin-4 inhibits iNOS expression at the protein level in LPS-stimulated Raw264.7 macrophage by the activation of cAMP/PKA pathway