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A narrative review concluded that the practice is controversial because there are no standardized dosing protocols and nearly onethird of patients report adverse effects, ranging from mild gastrointestinal symptoms to liver dysfunction and lifethreatening allergic reactions

Neurology 55 , 8388 (2000)

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Colon contents were homogenized with methanol at a 14 (w/v) ratio, while serum samples were mixed with methanol at a 19 (v/v) ratio

After written consent was obtained, the desensitisation procedure began with 15-min intervals, and the desensitisation process started with increasing doses, one, two and four-week intervals, were similar to literature