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Concentration ranges in published studies typically span 0.1 to 10 micromolar, with most significant gene expression effects observed at the 1 micromolar concentration used in the landmark Connectivity Map analysis
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Madhuranthakam, Vadim Malis, Sheng Qing Lin, Suraj Serai, Takeshi Yokoo, Scott B
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Similarly, the SELECT cardiovascular outcome trial, which followed over 17,000 patients with obesity but without diabetes for more than three years, found no significant elevation in cancer rates among semaglutide users
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