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Metformins senostatic action has been shown to improve frailty (including improvements in skeletal muscle mass and function in a mouse model of premature ageing [97]) and led to improvements in muscle strength and endurance in a sarcopenic mouse model, along with reduction in a suite of pro-inflammatory cytokines [98]

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When magnesium levels drop, muscles cannot fully relax after contracting, leading to chronic tension, cramping, and soreness