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doi: 10.1016/j.pharmthera.2022.108168 4 NohJYYangYJungH

Metabolic protection: They improve insulin sensitivity and protect against age-related metabolic disorders in animal models

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In addition, combining GLP-1R agonists with other peptide agonists or small-molecule therapeutics, including fibroblast growth factor 21 (FGF21), the farnesoid X receptor (FXR) agonist cilofexor with/without the acetyl coenzyme A carboxylase inhibitor firsocostat, a long-acting amylin agonist, cannabinoid receptor antagonists and sodium-glucose cotransporter 2 inhibitors (SGLT-2i), is currently being explored and may lead to additional improvements in NASH features vs GLP-1R agonists therapy alone [79,80,81,82,83]

Nature 263 , 797800 (1976)