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Alpha lipoic acid (50mg) is a naturally occurring antioxidant compound involved in energy metabolism
The most well-known examples, apart from pioglitazone, are fenofibrate, pemafibrate, seladelpar, elafibranor and lanifibranor, which have been studied in various trials regarding their effect on liver inflammation and fibrosis, without particular success, with the exception of lanifibranor, a pan-PPAR agonist, which was shown in a phase 2b RCT (NATIVE-NCT03008070) to improve ballooning and inflammation, without worsening of fibrosis
The favorable effects on atherogenic lipoproteins and hepatic steatosis indices support the pleiotropic benefits of semaglutide beyond glycemic control (18)
The recommended dietary allowance (RDA) for magnesium varies by age and gender but generally ranges from 310 to 420 milligrams per day for adults
This means the drug could be a lot longer acting reducing dosing to potentially just once every two months
