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Additional obstacles are the slow growth of NCs and their sensitivity to the external environment [58]

[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management

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doi: 10.1042/CS20171459 166 TessaroFHGAyalaTSMartinsJO