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CA, a diterpene compound, has been shown to exert strong antioxidant effects by reducing reactive oxygen species (ROS) and enhancing intracellular glutathione levels, which are essential for cellular redox balance and defense against oxidative damage

These inhibitors act on one or more targets with additive or synergistic effects, aiming to increase efficacy, prolong therapeutic effects, minimize side effects, and lower drug doses

4-HNE is a major end product of lipid peroxidation that is present in normal human plasma at concentrations ranging from 0.1M to 1.4M and this can increase more than 10 folds during oxidative stress in vivo [84]

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A study of rats exposed chronically to OTA, even at doses that resulted in 25% of the animals developing kidney tumor formation, the gene expression profile showed down-regulation of the antioxidant genes [73]