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For example, GLP-1 receptor agonists (e.g., liraglutide, semaglutide) have demonstrated not only potent weight-reducing and glycemic effects but also neuroprotective and antidepressant-like properties in both preclinical and clinical studies [74, 103, 104]

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High intensity trainings changes the immune response, thus raising biological markers of immune system such as natural killer cells (NK cells), T cells, B cells and increasing infection susceptibility