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Individual pools and combinations were evaluated for l-carnitineTMA activity using a fractional factorial design (Figure 6B)

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Approximately 90% of the intracellular APAP is metabolized by glucuronidation and sulfation pathways, whereas 510% is oxidized by cytochrome P450 (P450) enzymes to form the toxic metabolite NAPQI 18,19

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Iwaya, C., Nomiyama, T., Komatsu, S., Kawanami, T., Tsutsumi, Y., Hamaguchi, Y., Horikawa, T., Yoshinaga, Y., Yamashita, S., Tanaka, T., et al

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