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Acknowledgments The authors gratefully acknowledge the Board of the Instituto da Criana, Hospital das Clnicas, for their institutional support, with special thanks to Dr

Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds

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However, investors expected to see about 15% weight loss

129,130 They are believed to work in part by increasing the availability of serotonin and norepinephrine (also known as noradrenaline) in specific areas of the brain