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"When the doctor said on (the special) that (obesity is) like holding your breath underwater and trying not to rise, to me, that is the greatest metaphor," Winfrey said

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The medical community began noticing unusual patterns of vision loss among their patients using semaglutide medications, particularly cases of NAION that seemed to occur at higher rates than expected in the general population

doi: 10.1056/NEJMoa1607141 29 PratleyREArodaVRLingvayILdemannJAndreassenCNavarriaAet al

The perception of "ruined metabolism" often stems from the challenge of maintaining weight loss after discontinuation, which reflects the complex biology of weight regulation rather than drug-induced harm