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Because of an increased risk of diabetic ketoacidosis ketone monitoring in patients with type 1 diabetes and in others at risk for ketoacidosis (patients with type 2 diabetes on insulin therapy) should be considered, particularly when precipitating conditions for diabetic ketoacidosis occur such as acute febrile illness, reduced caloric intake, ketogenic diet, surgery, insulin dose reduction, volume depletion, or alcohol abuse
"Tirzepatide Once Weekly for the Treatment of Obesity." New England Journal of Medicine
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