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The mechanisms underlying their therapeutic efficacy are multifaceted, encompassing the competitive exclusion of pathogenic microorganisms from mucosal adhesion sites and the biosynthesis of antimicrobial metabolites that inhibit the proliferation of harmful microbes ( Table 3 Systemic therapeutic potential (oncology, gastroenterology, endocrinology (diabetes), cardiology, and neurology (gut-brain) of probiotics: a multi-disciplinary synthesis of mechanistic pathways and clinical efficacy

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