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In October 2023, the Journal of the American Medical Association examined adverse events associated with GLP-1 receptor agonists prescribed for weight loss, and researchers concluded that using the drugs increases the risk of gastrointestinal adverse effects, such as biliary disease, pancreatitis, bowel obstruction, and stomach paralysis
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But a more consequential signal emerged when looking beyond prescription counts to the patients themselves
Lower variability in drug exposure facilitates more predictable dose-response relationships and simplifies dose selection in clinical practice
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