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Under the induction of oxidative stress, a part of HIF-1 is translocated to mitochondria, where it inhibits the respiratory chain by lowering the expression of mtDNA-encoded mRNA that responses to hypoxia, thus preventing the over-production of ROS and resisting oxidative stress

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MAPK- Mitogen activated protein kinase

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Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation

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Farooq M, Usman M, Nadeem F, Rehman H, Wahid A, Basra SMA, et al

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