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In glutathione target genes-heart failure network analysis, 7 targets were identified, including tumor necrosis factor, vascular endothelial growth factor A, fibronectin 1, serine proteinase inhibitor 1, insulin-like growth factor binding protein 3, matrix metalloproteinase-1 and liquid oxygen, with serine proteinase inhibitor 1, insulin-like growth factor binding protein 3, fibronectin 1 and liquid oxygen significantly over expressed in heart failure

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However, the extent of GSH depletion required to impact triglyceride metabolism was unknown

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