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Supplementary Materials References 1.Hong ZX, Zhu ST, Li H, Luo JZ, Yang Y, An Y, Wang X, Wang K

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In the Phase 3 trial of once-weekly semaglutide for weight loss, lean body mass decreased, but the proportion of lean body mass relative to total body mass with semaglutide remained stable (earlier trials of 3.0 mg liraglutide did not report lean body mass proportions)

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GCG receptor null mice do not develop diabetes even with beta cell destruction, indicating that GCG receptor activation is necessary for diabetes development