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The discovery of sulfonamide antimicrobials in the early 1930s was heralded as a major advancement in the management of severe infectious diseases [1]

These include protective effects on the respiratory, reproductive, and cardiovascular systems, along with anti-hypoxic, anti-aging, anticancer, anti-inflammatory, and antioxidant properties (97)

This presents a meaningful clinical concern, particularly in populations exposed to polypharmacy or managing complex comorbidities

m , Venn diagram of differentially expressed genes in response to treatments

DMSA is extensively metabolized in humans to mixed disulfides of cysteine

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