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For example, one study found a single dose of Semax caused a 1.4-fold rise in hippocampal BDNF protein and upregulated its receptor (trkB)

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Concurrently, CXCL10 can promote osteoclastogenesis by regulating the expression of RANKL, which in turn accelerates cartilage and bone destruction in the joints of RA patients (Lee et al., 2017

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