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rather, they function as complementary agents that address an often overlooked metabolic component of autoimmunity

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these positive effectors increase manifold the affinity of ketoglutarate dehydrogenase complex to alpha-ketoglutarate

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We measured the markers of cardiac hypertrophy including MYH7 and ANP, NLRP3 inflammatory signaling pathway including NLRP3, Caspase-1, and IL-18 by Western-blot, and we detected the expression MYH7, ANP, NLRP3, and IL-18 by IHC in Sham group, TAC group, TAC + semaglutide group, and TAC + semaglutide + HCQ group, respectively