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An RCT of 174 patients with severe alcoholic hepatitis found that the combination of prednisolone + NAC (IV for 5 days, then oral for 2 weeks) significantly reduced 1-month mortality compared to prednisolone alone (8% vs 24%, p=0.006), though the difference was not significant at 6 months (Nguyen-Khac et al., N Engl J Med, 2011) [36]

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Claire Chang, MD, a board-certified dermatologist at UnionDerm in New York City

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In studies using SH-SY5Y cells, recognized as a model for studying neurodegenerative processes [53], melatonin exhibits an inhibitory effect on the expression of amyloidogenic -secretases [54]