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Abbasinejad can prescribe supportive medications for nausea or heartburn if needed during the adjustment period

10.1017/S0033291722000897 47 BorodyT

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Retention of this unmodified histidine in retatrutide preserves potent glucagon receptor agonism, which is a defining structural distinction compared to tirzepatide, where this position is also histidine but the molecule lacks meaningful glucagon receptor activity due to other sequence differences