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The transcriptional upregulation of Ppara and Ppargc1a observed here reflects glucagon-driven mitochondrial activation [49], while the downregulation of lipogenic genes ( Fasn , Scd2 ) may stem from GIP receptor activation in adipocytes, redirecting nutrient flux away from storage

(2011) 106 Suppl 3:S578

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CONTRAVE is believed to work on the hypothalamus (appetite regulatory center) and dopamine reward system in the brain to regulate appetite