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The price discount required to achieve formulary positioning also varies: interchangeable biosimilars have sometimes achieved formulary placement at lower discounts because the payer values the operational ease of pharmacy-level substitution

Nat Rev Gastroenterol Hepatol 14(6):343355 Guo L, Kang JS, Park YH, Je BI, Lee YJ, Kang NJ, Park SY, Hwang DY, Choi YW (2020) S-petasin inhibits lipid accumulation in oleic acid-induced HepG2 cells through activation of the AMPK signaling pathway

The cells were gently vortexed and incubated for 15 min at room temperature (25 C) in the dark

The US FDA label indications for these molecules are shown in Table 2

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