10.1083/jcb.201412147 J Cell Biol
It can occur spontaneously, after prior radiation exposure, or from transformation of benign plexiform neurofibromas, especially in people with Neurofibromatosis type 1 (NF1)
Erratic application sends mixed signals
Preclinical studies in mice demonstrate significant reductions in fat mass and body weight without changes in food intake
The prognostic variability of acute exacerbation seems to be influenced by various kinds of clinical conditions such as sex, age, pathological patterns including not only of diffuse alveolar damage, but also organizing pneumonia, pulmonary thromboembolism, diffuse alveolar hemorrhage, and bronchopneumonia, and comorbidities 5,6,7
Rather than treating these domains independently, we propose a unifying framework in which melatonin functions as a physiological hub coordinating temporal organization and cellular protection