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Briefly, when either caspase 8 or fas-associated via death domain (FADD) is depleted or the function is inhibited, TNF can induce caspase 8 independent necrosis through activating RIPK1 (receptor interacting serine/threonine kinase 1) [94]

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doi: 10.1016/j.advms.2017.05.005 20 SenguptaPDuttaSSlamaPRoychoudhuryS

ET-1 has been shown to regulate the expression of LOX-1 through the ET-1 receptor in endothelial cells

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Determination of hepatic lipid content Liver samples were grinded and subjected to lipid extraction with chloroform: methanol (2:1) as described by Folch, Lees and Stanley (1957)