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Phenylalanine hydroxylase deficiency: diagnosis and management guideline

To further elucidate the therapeutic mechanisms underlying D-CuPs multivalent interactions, comprehensive proteomic analysis revealed two pivotal transcriptional regulators, the tumor suppressor protein p53 and histone deacetylase 7 (HDAC7) to be potential mechanistic targets

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GSH is an essential antioxidant in brain cells that detoxifies reactive oxygen species, and in vitro studies have linked GSH homeostasis disruption to oxidative stress in neurological diseases [14, 72]