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We initially sought to introduce DJX-A-KM analogues bearing an alkyne handle into the linker region of DJX-A-KM and into the naphthalene structure of MRTX849 for conventional chemical proteomics analysis ( DJX-A-KQ and DJX-3115 , Supplementary Table 1)

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Administration of acetyl-L-carnitine, an acetylated form of L-carnitine improved the mental status to normal levels and resolved hyperammonemia in a patient on chronic hemodialysis who exhibited elevated serum ammonia levels and altered mental status (38)

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