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Clinical trials show moderate evidence for pain reduction over 8 to 24 weeks, particularly in aging populations

Plus, studies show intravenous administration of vitamin C achieves 70-fold higher blood levels of this vitamin than the highest tolerated oral dose

SAM's many roles: SAM is the primary methyl donor, used in DNA/RNA methylation, protein modification, and synthesis of neurotransmitters and hormones

Reviewed by FDA against compounding inclusion in December 2024

Side Effects Injection Site Reactions : Pain, redness, or itching at the injection site are typical adverse effects

Not taking B12 supplements or regularly eating B12 fortified foods may explain the higher stroke