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In vitro, 5-Amino-1MQ at 30 M in 3T3-L1 adipocytes significantly reduced intracellular 1-MNA levels, confirming NNMT target engagement

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In a study published in December 2018 in Nutrients , 30 adults with no chronic disease experienced severe diarrhea and GI symptoms such as bloating and nausea after ingesting 0.5 grams of allulose per kilogram of body weight in a single serving, but they had no symptoms at lesser amounts