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Ferroptosis is characterized by the depletion of intracellular GSH and decreased activity of GPx4, which in turn results in the accumulation of lipid peroxides and Fe(II)-catalyzed oxidation of lipids by the Fenton reaction and increased ROS formation

Non-esterified fatty acids (NEFAs) activate the TLR4/NF-B pathway in granulosa cells, increasing NLRP3 and caspase-1 levels, along with the release of IL-1 and IL-6, leading to OS, pyroptosis, and inflammation (Wang Y

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Barrier function starts improving as GHK-Cu activates ceramide and structural protein production

These molecules exhibit a range of biological activities, such as antioxidant, antiinflammatory, and ion-modulating effects, which collectively contribute to the inhibition of the apoptotic process

Retinoid drugs include acitretin (Soriatane) and isotretinoin (Accutane)