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Furthermore, its use for skin lightening has been associated with severe side effects
Critical Reviews in Biochemistry and Molecular Biology , 50 (3), 21230

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Hyperhomocysteinemia decreases GSH peroxidase activity leading to the prevalence of GSSG on GSH with the GSH/GSSG impaired ratio causing some common cardiovascular and neurodegenerative disorders (159)
While QCN has well-established anti-inflammatory and antioxidant properties, its poor solubility and limited bioavailability restrict vascular penetration and limit sustained therapeutic efficacy 54,84