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Targeting myeloid-derived suppressor cell, a promising strategy to overcome resistance to immune checkpoint inhibitors

Daily treatment with CARN for 5 days before and after a single dose of MTX achieved 4.8-fold and 26.5-fold elevation in serum total carnitine and 3.57-fold and 22.6-fold elevation in serum-free carnitine level compared with control and MTX-MD groups, respectively

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Understanding the expected side effect profile is essential for distinguishing between common, self-limiting reactions and those requiring urgent medical evaluation

But the full picture deserves more nuance than a simple rejection