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Nat Rev Cancer (2012) 12(12):83548.10.1038/nrc3397 62 VauzourDRodriguez-MateosACoronaGOruna-ConchaMJSpencerJP

10.1007/s10637-022-01284-w 39 EadsJ

A technical review notes that DSM-Firmenich states alpha arbutin is nine times more effective than beta-arbutin in tyrosinase inhibition , and that the SCCS has suggested safe use concentrations up to 2% in face creams and up to 0.5% in body lotions , according to this review of alpha arbutin applications

54 , e13145 (2021)

Lyophilization precision freeze-drying removes water under vacuum so the molecule can be stored at room temperature or frozen until reconstitution

Sublingual routes of administration have certain advantages over simple oral administration